Methyl iodide → HCID 13191642, compound

HRID 1463054Notes

Reaction equation

HRID 1463054 reaction equation
[N:1]1[C:13]2[N:4]([C:5](=[O:14])[N:6]=[C:7]3[C:12]=2[CH:11]=[CH:10][CH:9]=[CH:8]3)[NH:3][C:2]=1[C:15]([O:17][CH2:18][CH3:19])=[O:16].[H-].[Na+].[CH3:22]I>CN(C)C=O>[CH3:22][N:6]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:12]=2[C:13]2=[N:1][C:2]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[N:3][N:4]2[C:5]1=[O:14]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 178470148HCID 178470148, compound

Product 1

HCID 13191642HCID 13191642, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent2×

Procedure

12.0 g (0.047 mole) of ethyl 1,2,4-triazolo[1,5-c]quinazolin-5-one-2-carboxylate in 100 ml of absolute dimethylformamide were added dropwise to a suspension of 0.053 mole of NaH in 100 ml of absolute dimethylformamide at room temperature. After 2 hours, 7.5 g (0.053 mole) of methyl iodide were added, and the mixture was stirred overnight at room temperature and then poured into 400 ml of ice water. The precipitate was filtered off under suction and dried. Yield: 6.6 g (52%), mp.: 258° C.

Workup

  1. filtrationThe precipitate was filtered off under suction
  2. customdried

Sources & evidence

ORD record
ord-d0033569bbfe4b0b873a57bc903071ec
Source dataset
uspto-grants-1984_07
Patent number
US04463007

Reaction notes

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