Hydrochloric Acid → HCID 178448682, compound

HRID 1463076Notes

Reaction equation

HRID 1463076 reaction equation
[C:1]([O:7]CC)(=O)[CH2:2][C:3]([CH3:5])=O.[C:10]([CH2:12][C:13]([O:15]C)=O)#[N:11].[CH:17]([NH2:21])([CH2:19][CH3:20])[CH3:18].Cl>CO>[CH:17]([N:21]1[C:1]([OH:7])=[CH:2][C:3]([CH3:5])=[C:12]([C:10]#[N:11])[C:13]1=[O:15])([CH2:19][CH3:20])[CH3:18]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 7747Methyl cyanoacetateHCID 8868Ethyl AcetoacetateHCID 24874Sec-Butylamine

Product 1

HCID 178448682HCID 178448682, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture composed of 130 g (1 mol) of ethyl acetoacetate, 99 g (1 mol) of methyl cyanoacetate, 146 g (2 mol) of sec-butylamine and 300 ml of methanol was heated in an autoclave at 100° to 110° C. for 10 hours. After cooling, the reaction solution was neutralized with diluted hydrochloride to obtain white crystals of 1-sec-butyl-3-cyano-6-hydroxy-4-methyl-2-pyridone.

Workup

  1. temperaturewas heated in an autoclave at 100° to 110° C. for 10 hours
  2. temperatureAfter cooling

Sources & evidence

ORD record
ord-c1289dd1aca34003af68f01de4c103c8
Source dataset
uspto-grants-1984_07
Patent number
US04463079

Reaction notes

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