Lithium iodide → HCID 86747755, compound

HRID 1463973Notes

Reaction equation

HRID 1463973 reaction equation
[N+](C1C=CC(C[N:9]2[CH:12]([CH2:13][CH2:14][C:15]3[O:16][CH:17]=[CH:18][CH:19]=3)[CH:11]([N:20]3[C@@H:24]([C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=4)[CH2:23][O:22][C:21]3=[O:31])[C:10]2=[O:32])=CC=1)([O-])=O.[C:35]([O-:38])(=[O:37])[CH3:36].[I-].[Li+]>C(OCC)(=O)C>[C:25]1([C@H:24]2[CH2:23][O:22][C:21](=[O:31])[N:20]2[CH:11]2[CH:12]([CH2:13][CH2:14][C:15]3[O:16][CH:17]=[CH:18][CH:19]=3)[NH:9][C:10]2=[O:32])[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1.[C:35]([OH:38])(=[O:37])[CH3:36]

Participants

4

Reactant 2

HCID 66321Lithium iodideHCID 86747757HCID 86747757, compound

Product 1

HCID 86747755HCID 86747755, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The titled compound was prepared substantially in accordance with the method detailed in Example 1 using 2.60 g (5 mmol) of p-nitrobenzyl-3-[(S)-4-phenyloxazolidin-2-one-3-yl]-4-[2-furylethyl]-azetidin-2-one-1-ethanoate, 20 ml of ethyl acetate and 2.0 g (15 mmol) of lithium iodide. The reaction mixture was allowed to react for approximately 71/2 hours at reflux temperature to provide 1.54 g of a light yellow solid.

Workup

  1. customto react for approximately 71/2 hours
  2. temperatureat reflux temperature

Sources & evidence

ORD record
ord-fa88b1753fc041f4b568b6c2742aa8ff
Source dataset
uspto-grants-1994_04
Patent number
US05302711

Reaction notes

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