Hydrochloric Acid → HCID 178430921, compound

HRID 1463982Notes

Reaction equation

HRID 1463982 reaction equation
[NH2:1][C:2]1[N:6](/[CH:7]=[CH:8]/OCC)[N:5]=[CH:4][C:3]=1[CH3:12].Cl.C(OCC)(=O)C>O1CCCC1>[CH3:12][C:3]1[CH:4]=[N:5][N:6]2[CH:7]=[CH:8][NH:1][C:2]=12

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 19089117HCID 19089117, compound

Product 1

HCID 178430921HCID 178430921, compoundYield 90.1%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 5-amino-4-methyl-1-[(E)-2-ethoxyvinyl]pyrazole (10.6 g) in tetrahydrofuran (212 ml) was added 4N hydrochloric acid, and the mixture was refluxed for 3 hours. The reaction mixture was adjusted to pH 8 under ice-cooling, thereto was added ethyl acetate (100 ml). The separated organic layer was dried over magnesium sulfate and evaporated in vacuo to give 7-methyl-1H-imidazo[1,2-b]pyrazole (6.92 g) as crystals.

Workup

  1. temperaturethe mixture was refluxed for 3 hours
  2. temperaturecooling
  3. dry with materialThe separated organic layer was dried over magnesium sulfate
  4. customevaporated in vacuo

Sources & evidence

ORD record
ord-9bd1f373ed2141c98b0aaba28d0c6f41
Source dataset
uspto-grants-1994_04
Patent number
US05302712

Reaction notes

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