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HRID14643

反应详情

EQUATION

反应方程式

HRID 14643 的结构方程式

REACTANTS

反应物

2
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：COc1cc(OC)c2c(CNC(=O)OC(C)(C)C)ncc(C(=O)N(C)C(C)c3ccccc3)c2c1
HCID68613798

未命名化合物

PRODUCTS

生成物

1
结构：COc1cc(OC)c2c(CN)ncc(C(=O)N(C)C(C)c3ccccc3)c2c1.Cl
HCID68614786

未命名化合物

收率 97%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

As described in example 1, 112 mg of {6,8-dimethoxy-4-[methyl-(1-phenyl-ethyl)-carbamoyl]-isoquinolin-1-ylmethyl}-carbamic acid tert-butyl ester was treated with HCl in EtOAc to give 86 mg (97%) of 1-aminomethyl-6,8-dimethoxy-isoquinoline-4-carboxylic acid methyl-(1-phenyl-ethyl)-amide hydrochloride. MS: APCI (M+H) calc'd for C22H25N3O3+H 380.5; found 380.2.