4-Bromophenol → 1-Bromo-4-(methoxymethoxy)benzene

HRID 1464435Notes

Reaction equation

HRID 1464435 reaction equation
[CH3:1][O:2][CH2:3][O:4][CH3:5].[Br:6][C:7]1[CH:12]=[CH:11]C(O)=[CH:9][CH:8]=1>>[CH3:1][O:2][CH2:3][O:4][C:5]1[CH:11]=[CH:12][C:7]([Br:6])=[CH:8][CH:9]=1

Participants

3

Reactant 2

HCID 78084-BromophenolHCID 8020Dimethoxymethane

Product 1

HCID 104659191-Bromo-4-(methoxymethoxy)benzeneYield 49%

Procedure

4-Methoxymethoxy-1-bromobenzene was prepared from formaldehyde dimethyl acetal and 4-bromophenol by the method of Y. P. Yardley and H. Fletcher, Synthesis 1976. p. 244. The boiling point of this derivative is 54°-56° C. at 0.1 hPa, and the yield is 49% of theory.

Workup

  1. customFletcher, Synthesis 1976
  2. customthis derivative is 54°-56° C. at 0.1 hPa

Sources & evidence

ORD record
ord-8ea7403dc76c45fd89822a787cb3221b
Source dataset
uspto-grants-1994_04
Patent number
US05304667

Reaction notes

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