反应详情

温度

90 °C

A mixture of 6-chloropyridine-3-carbonitrile (7.0 g, 50 mmol), allyl tri-n-butyltin (18.2 g, 55.0 mmol) and Pd(PPh3)2Cl2 (1 g) in 80 mL DMF was stirred at 90° C. for 3 hours. The mixture was cooled down and diluted with 1 L of EtOAc, washed with water (100 mL×2) and brine (100 mL), then concentrated. The residue was purified by column chromatography (PE:EtOAc=10:1) to afford the title compound.

1. temperatureThe mixture was cooled down
2. washwashed with water (100 mL×2) and brine (100 mL)
3. concentrationconcentrated
4. customThe residue was purified by column chromatography (PE:EtOAc=10:1)