Trifluoroacetic acid → HCID 56591357, compound

HRID 1467328Notes

Reaction equation

HRID 1467328 reaction equation
FC(F)(F)C(O)=O.[C:8]1([CH:14]2[CH2:19][CH:18]([NH:20][C:21]([C:23]3[CH:24]=[C:25]4[C:29](=[CH:30][CH:31]=3)[N:28](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[N:27]=[C:26]4[C:51]3[CH:56]=[CH:55][N:54]=[CH:53][CH:52]=3)=[O:22])[CH2:17][N:16](C(OCCCC)=O)[CH2:15]2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>C([SiH](CC)CC)C>[C:8]1([CH:14]2[CH2:15][NH:16][CH2:17][CH:18]([NH:20][C:21]([C:23]3[CH:24]=[C:25]4[C:29](=[CH:30][CH:31]=3)[NH:28][N:27]=[C:26]4[C:51]3[CH:52]=[CH:53][N:54]=[CH:55][CH:56]=3)=[O:22])[CH2:19]2)[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86681280HCID 86681280, compound

Product 1

HCID 56591357HCID 56591357, compound

Reagents, catalysts & solvents 1

HCID 12052TriethylsilaneCatalyst

Procedure

Trifluoroacetic acid (1 mL) was added to tort-butyl 3-phenyl-5-(3-(pyridin-4-yl)-1-trityl-1H-indazole-5-carboxamido)piperidine-1-carboxylate (0.104 mmol). The reaction was stirred at room temperature for 30 minutes. Triethylsilane (1 drop) was added to the reaction and stirred for an additional 5 minutes. The reaction was concentrated in vacuo and purified using prep LC/MS.

Workup

  1. stirringstirred for an additional 5 minutes
  2. concentrationThe reaction was concentrated in vacuo
  3. custompurified

Sources & evidence

ORD record
ord-3b542e20659e49e5ba72eeeb51aa4d3f
Source dataset
uspto-grants-2015_04
Patent number
US08999957B2

Reaction notes

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