反应详情

Boc-Glu-OtBu (75 mg, 0.247 mmol), HATU (112 mg, 0.296 mmol) and HOAt (41 mg, 0.296 mmol) were dissolved in 1 ml of DMF, and triethylamine (52 μl) was added to the solution. The mixture was stirred at room temperature for 10 minutes. 3-Sulfoaniline (43 mg, 0.247 mmol) was added to the mixture, followed by stirring at room temperature overnight. After the solvent was removed by distillation, the mixture was purified according to the purification step A. The resulting intermediate was dissolved in 2 ml of trifluoroacetic acid. After stirring for 3 hours at room temperature, the solvent was distilled off. The product was purified using the purification step A to give the title compound.

1. stirringby stirring at room temperature overnight
2. customAfter the solvent was removed by distillation
3. customthe mixture was purified
4. customaccording to the purification step A
5. dissolutionThe resulting intermediate was dissolved in 2 ml of trifluoroacetic acid
6. stirringAfter stirring for 3 hours at room temperature
7. distillationthe solvent was distilled off
8. customThe product was purified
9. customthe purification step A