反应详情

After 1 ml of methylene chloride and 1 ml of THF were added to 303 mg (1 mmol) of Boc-Glu-OtBu hydrochloride and 180 mg (1.1 mmol) of CDI, 221 mg of 5-amino-3-chloro-2-methylbenzenesulfonic acid was further added to mixture. The mixture was stirred at room temperature overnight and then purified in accordance with the purification step A to give the protected product. The protected product obtained was dissolved in 5 ml of trifluoroacetic acid. The solution was stirred for 2 hours. The solvent was distilled off and the mixture was purified in accordance with the purification step A to give the title compound.

1. additionwas further added to mixture
2. custompurified in accordance with the purification step A
3. customto give the protected product
4. customThe protected product obtained
5. stirringThe solution was stirred for 2 hours
6. distillationThe solvent was distilled off
7. customthe mixture was purified in accordance with the purification step A