反应详情

温度

120 °C

To a stirred solution of 3-bromoisoquinoline (Intermediate-12) (9.2 g, 44.2 mmol) in DMF (15 mL) were added, Pd(PPh3)4 (10.2 g, 8.84 mmol) and Zn(CN)2 (10.34 g, 88.44 mmol, 2.0 eq) and the solution was degassed with N2 for 20 min. It was then heated to 120° C. overnight. After the completion (TLC), reaction mixture was cooled to RT, filtered and concentrated under reduced pressure. The crude product obtained was purified by flash column chromatography (10% EtOAc:Hexanes) to afford the desired compound (3.4 g, 27.4%) as pale yellow solid.

1. customAfter the completion (TLC), reaction mixture
2. temperaturewas cooled to RT
3. filtrationfiltered
4. concentrationconcentrated under reduced pressure
5. customThe crude product obtained
6. customwas purified by flash column chromatography (10% EtOAc:Hexanes)