Hydrochloric Acid → HCID 85085907, compound

HRID 1470595Notes

Reaction equation

HRID 1470595 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[CH:4][CH:3]=1.Cl[C:10](Cl)(Cl)[CH:11]([OH:13])O.S([O-])([O-])(=O)=O.[Na+].[Na+].Cl.[NH2:24][OH:25].Cl>O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:11](=[O:13])[CH:10]=[N:24][OH:25])=[CH:4][CH:3]=1

Participants

7

Reactant 5

HCID 313Hydrochloric AcidHCID 2707Chloral HydrateHCID 78074-BromoanilineHCID 24436Sodium SulfateHCID 443297Hydroxyamine hydrochloride

Product 1

HCID 85085907HCID 85085907, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
85 °C

Procedure

To a slurry of 4-bromo-phenylamine (10 g, 58.13 mmol) in water (200 mL) was added chloral hydrate (11.65 g, 69.76 mmol), sodium sulphate (50 g), hydroxylamine hydrochloride (12.8 g, 186 mmol) and conc. HCl (15 mL). The reaction mixture was then heated to 85° C. and stirred for another 2 h. After completion of the reaction, a solid separated out. The mixture was cooled to room temperature, filtered and washed with water (2-3 times) and dried to obtain the title compound as off white solid (12 g, 84.9%).

Workup

  1. customAfter completion of the reaction
  2. customa solid separated out
  3. temperatureThe mixture was cooled to room temperature
  4. filtrationfiltered
  5. washwashed with water (2-3 times)
  6. customdried

Sources & evidence

ORD record
ord-b51904f41b5f475aa3ec170d722dd082
Source dataset
uspto-grants-2015_04
Patent number
US09006454B2

Reaction notes

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