Chloral Hydrate → HCID 6708874, compound

HRID 1470601Notes

Reaction equation

HRID 1470601 reaction equation
Cl[C:2](Cl)(Cl)[CH:3]([OH:5])O.Cl.[NH2:9][OH:10].S([O-])([O-])(=O)=O.[Na+].[Na+].[NH2:18][C:19]1[CH:24]=[CH:23][C:22]([CH3:25])=[CH:21][CH:20]=1>O.Cl>[OH:10][N:9]=[CH:2][C:3]([NH:18][C:19]1[CH:24]=[CH:23][C:22]([CH3:25])=[CH:21][CH:20]=1)=[O:5]

Participants

7

Reactant 4

HCID 2707Chloral HydrateHCID 7813p-ToluidineHCID 24436Sodium SulfateHCID 443297Hydroxyamine hydrochloride

Product 1

HCID 6708874HCID 6708874, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 962WaterSolvent

Procedure

A solution of chloral hydrate (38 g, 0.223 mol), hydroxylamine hydrochloride (41 g, 0.594 mol) and sodium sulphate (40 g, 0.281 mol) in water (800 mL) was heated to 90° C. To this mixture was added a solution of p-toluidine (20 g, 0.1866 mol) in conc. HCl (30 mL) The resulting mixture was stirred for another 2 h. After the reaction is completed, the reaction mixture was cooled to room temperature, the precipitate was filtered and washed with water (100 mL). The solid was dried in a vacuum oven to get the required product as a grey coloured solid.

Workup

  1. filtrationthe precipitate was filtered
  2. washwashed with water (100 mL)
  3. customThe solid was dried in a vacuum oven

Sources & evidence

ORD record
ord-6821d16f162d4a31b994f2b6d9b5b4d9
Source dataset
uspto-grants-2015_04
Patent number
US09006454B2

Reaction notes

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