Hydrochloric Acid → HCID 86708889, compound

HRID 1471433Notes

Reaction equation

HRID 1471433 reaction equation
[CH3:1][N:2]1[CH:6]=[C:5]([N:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[C:9]([C:16]([O:18]C)=[O:17])=[CH:8]2)[CH:4]=[N:3]1.C(O)(C(F)(F)F)=O.[OH-].[K+].[ClH:29]>CO>[ClH:29].[CH3:1][N:2]1[CH:6]=[C:5]([N:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[C:9]([C:16]([OH:18])=[O:17])=[CH:8]2)[CH:4]=[N:3]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 6422Trifluoroacetic acidHCID 14797Potassium HydroxideHCID 86708891HCID 86708891, compound

Product 1

HCID 86708889HCID 86708889, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of methyl 1-(1-methyl-1H-pyrazol-4-yl)-1H-indole-3-carboxylate, TFA (3.5 mg, 9.48 μmol) in MeOH (95 μl) was added a solution of aq. KOH (33.2 μl, 0.066 mmol, 2 M). The reaction mixture was stirred at RT overnight, then acidified with 1N HCl. The solvent was evaporated under reduced pressure and the residue was dried under vacuum overnight. The title compound was used without further purification.

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customthe residue was dried under vacuum overnight
  3. customThe title compound was used without further purification

Sources & evidence

ORD record
ord-8ea42ac98f30467f8cb278473db8941c
Source dataset
uspto-grants-2015_04
Patent number
US09012447B2

Reaction notes

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