Diethyl (ethoxymethylene)malonate → HCID 67281873, compound

HRID 1471809Notes

Reaction equation

HRID 1471809 reaction equation
Cl.C[C:3]1[CH:7]=[CH:6][NH:5][C:4]=1[C:8]([O:10][CH2:11][CH3:12])=[O:9].C([N:16](C(C)C)CC)(C)C.C(O[CH:25]=[C:26]([C:32]([O:34][CH2:35][CH3:36])=[O:33])[C:27]([O:29][CH2:30][CH3:31])=[O:28])C>>[CH2:11]([O:10][C:8]([C:4]1[NH:5][CH:6]=[CH:7][C:3]=1[NH:16][CH:25]=[C:26]([C:32]([O:34][CH2:35][CH3:36])=[O:33])[C:27]([O:29][CH2:30][CH3:31])=[O:28])=[O:9])[CH3:12]

Participants

4

Reactant 3

HCID 6871Diethyl (ethoxymethylene)malonateHCID 81531DiisopropylethylamineHCID 67282538HCID 67282538, compound

Product 1

HCID 67281873HCID 67281873, compound

Conditions

Temperature
100 °C

Procedure

Equimolar ratios of ethyl 3-methyl-1H-pyrrole-2-carboxylate hydrochloride, diisopropylethylamine and diethyl ethoxymethylenemalonate were mixed in a sealed tube and heated at 100° C. for 15 hours. After cooling to room temperature, column chromatography afforded the title compound as a white solid.

Workup

  1. temperatureAfter cooling to room temperature

Sources & evidence

ORD record
ord-d46d0281a52a4db4a7aa719cbc4d2d53
Source dataset
uspto-grants-2015_04
Patent number
US09012470B2

Reaction notes

Loading…