反应详情

Cyclohexylmandelic acid (885 mg, 3.78 mmol) was added to tert-butyl 4-(bromomethyl)piperidine-1-carboxylate (957 mg, 3.44 mmol) and potassium carbonate (713 mg) in dimethyl formamide (10 mL) at RT with stirring. After 72 hours, the reaction was diluted with ethyl acetate and water. The organic extracts were washed with saturated sodium chloride solution, dried (sodium sulfate), filtered, and concentrated under reduced pressure. The crude reaction mixture was purified by silica gel column chromatography eluting with 0-30% ethyl acetate in iso-hexane to afford the title compound (1.10 g, 75%).

1. washThe organic extracts were washed with saturated sodium chloride solution
2. dry with materialdried (sodium sulfate)
3. filtrationfiltered
4. concentrationconcentrated under reduced pressure
5. customThe crude reaction mixture
6. customwas purified by silica gel column chromatography
7. washeluting with 0-30% ethyl acetate in iso-hexane