反应详情

A three-neck 2 L flask equipped with an overhead stirrer, a thermocouple and a nitrogen inlet was charged with 6-bromo-1-chloroisoquinoline (60.0 g, 247 mmol), xantphos (7.16 g, 12.4 mmol) and Pd2(dba)3 (5.66 g, 6.19 mmol) in that order. The flask was evacuated. To the reaction flask was charged sparged dioxane (540 mL) and DIPEA (64.8 mL, 371 mmol). The flask was purged with N2 and warmed to 63° C. upon which a solution of phenylmethanethiol (30.5 mL, 260 mmol) in 180 mL of sparged dioxane was charged to the reaction mixture dropwise over 1 hr. The reaction was completed according to LC/MS. The solids were filtered off. The filtrate was concentrated down to a low volume. 500 mL of isopropanol was added into a separate flask. The concentrated product solution was charged slowly to the flask containing isopropanol. The product crystallized out of the solution. The resulting slurry was stirred at RT for 2 hours. The slurry was cooled to 0° C., filtered, washed with 50% IPA/heptanes, and dried under a vacuum with nitrogen sweep. The product was obtained as yellow solids (44.3 g; 63% isolated yield). 1H NMR (400 MHz, CHLOROFORM-d) δ ppm=8.26-8.10 (m, 2H), 7.63-7.51 (m, 2H), 7.46-7.39 (m, 3H), 7.37-7.28 (m, 3H), 4.31 (s, 2H); m/z (ESI) 286.2 (M+H)+.

1. customA three-neck 2 L flask equipped with an overhead stirrer
2. customThe flask was evacuated
3. additionTo the reaction flask was charged
4. customThe flask was purged with N2
5. additionwas charged to the reaction mixture dropwise over 1 hr
6. filtrationThe solids were filtered off
7. concentrationThe filtrate was concentrated down to a low volume
8. addition500 mL of isopropanol was added into a separate flask
9. additionThe concentrated product solution was charged slowly to the flask
10. additioncontaining isopropanol
11. customThe product crystallized out of the solution
12. temperatureThe slurry was cooled to 0° C.
13. filtrationfiltered
14. washwashed with 50% IPA/heptanes
15. customdried under a vacuum with nitrogen sweep
16. customThe product was obtained as yellow solids (44.3 g; 63% isolated yield)