反应详情

4-Bromo-3-chlorophenol (1 g, 4.82 mmol) was dissolved in DMF (10 ml) and K2CO3 (1.332 g, 9.64 mmol) and benzyl bromide (0.630 ml, 5.30 mmol) added. The mixture was stirred under N2 for 1 hr at RT. The mixture was diluted with water (15 mL) and extracted with EtOAc (2×10 mL). The organic fractions were combined, washed with brine (saturated, 1×8 mL), dried over MgSO4, filtered and the volatiles removed in vacuo. The residue was purified by column chromatography on silica gel Biotage 25M, using a gradient eluant of EtOAc/Hexane (0-50%) to afford the title compound. LC/MS (m/z): 297 (M+H)+.

1. extractionextracted with EtOAc (2×10 mL)
2. washwashed with brine (saturated, 1×8 mL)
3. dry with materialdried over MgSO4
4. filtrationfiltered
5. customthe volatiles removed in vacuo
6. customThe residue was purified by column chromatography on silica gel Biotage 25M