Hydrochloric Acid → HCID 86724026, compound

HRID 1475457Notes

Reaction equation

HRID 1475457 reaction equation
[ClH:1].C(OC([N:9]1[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([Br:18])[CH:16]=2)[C:11]([CH2:20][O:21][CH3:22])([CH3:19])[CH2:10]1)=O)(C)(C)C>CCOC(C)=O>[ClH:1].[Br:18][C:15]1[CH:16]=[C:17]2[C:12]([C:11]([CH2:20][O:21][CH3:22])([CH3:19])[CH2:10][NH:9]2)=[CH:13][CH:14]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 70980248HCID 70980248, compound

Product 1

HCID 86724026HCID 86724026, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Saturated HCl in EtOAc (10 mL) was added to 6-bromo-3-methoxymethyl-3-methyl-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester (300 mg, 0.84 mmol) and the mixture was stirred at room temperature for 1 h. The solvent was removed in vacuo, the solid was washed with Et2O and dried in vacuo to give the title compound (220 mg) as a yellow semi-solid. MS: [M+H]+=256.

Workup

  1. customThe solvent was removed in vacuo
  2. washthe solid was washed with Et2O
  3. customdried in vacuo

Sources & evidence

ORD record
ord-27163cfe51574eb0a5b19ab47013d18e
Source dataset
uspto-grants-2015_04
Patent number
US09018214B2

Reaction notes

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