Hydrochloric Acid → 2-Ethyl-6-fluoro-3-phenyl-4H-chromen-4-one

HRID 1476162Notes

Reaction equation

HRID 1476162 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([OH:17])=[C:6]([C:8](=[O:16])[CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:7]=1.[C:18](OC(=O)CC)(=O)[CH2:19][CH3:20].Cl>C(N(CC)CC)C>[CH2:19]([C:20]1[O:17][C:5]2[C:6]([C:8](=[O:16])[C:9]=1[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[CH:7][C:2]([F:1])=[CH:3][CH:4]=2)[CH3:18]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 31263Propionic anhydrideHCID 27785851-(5-Fluoro-2-hydroxyphenyl)-2-phenylethanone

Product 1

HCID 602090512-Ethyl-6-fluoro-3-phenyl-4H-chromen-4-oneYield 65%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Intermediate 50 (3.0 g, 13.63 mmoles) was taken in a RB flask and to this triethylamine (30 ml) and propionic anhydride (5.30 g, 40.78 mmoles) were added and the mixture was refluxed for 24 h. After cooling to RT, the reaction mixture was acidified by the addition of 1N HCl solution, extracted with ethyl acetate, washed with sodium bicarbonate solution, dried with sodium sulphate and concentrated. The crude product was purified by column chromatography with ethyl acetate:petroleum ether to afford the title compound as off-white solid (2.27 g, 65% yield). 1H-NMR (δ ppm, DMSO-d6, 400 MHz): δ 7.79(dd, J=7.1, 4.4Hz, 1H), 7.73(dt, J=7.7,3.1 Hz, 2H), 7.46(t, J=8.2Hz, 2H), 7.40(m, 1H), 7.27 (dd, J=8.2,1.4 Hz, 2H), 2.55(q, J=7.5Hz, 2H), 1.19(t, J=7.6Hz, 3H).

Workup

  1. additionwere added
  2. temperaturethe mixture was refluxed for 24 h
  3. extractionextracted with ethyl acetate
  4. washwashed with sodium bicarbonate solution
  5. dry with materialdried with sodium sulphate
  6. concentrationconcentrated
  7. customThe crude product was purified by column chromatography with ethyl acetate

Sources & evidence

ORD record
ord-89518f6c3f1442699551a0bdb28c1661
Source dataset
uspto-grants-2015_04
Patent number
US09018375B2

Reaction notes

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