Hydrochloric Acid → HCID 118390062, compound

HRID 1478066Notes

Reaction equation

HRID 1478066 reaction equation
[Cl:1][C:2]1[C:3]([NH:17][CH:18]2[CH2:35][CH2:34][C:21]3([CH2:26][CH2:25][N:24](C(OC(C)(C)C)=O)[CH2:23][CH2:22]3)[CH2:20][CH2:19]2)=[N:4][C:5]([NH:8][C:9]2[CH:13]=[C:12]([CH:14]3[CH2:16][CH2:15]3)[NH:11][N:10]=2)=[N:6][CH:7]=1.Cl.C(OCC)(=O)C>C(Cl)Cl>[ClH:1].[Cl:1][C:2]1[C:3]([NH:17][CH:18]2[CH2:35][CH2:34][C:21]3([CH2:26][CH2:25][NH:24][CH2:23][CH2:22]3)[CH2:20][CH2:19]2)=[N:4][C:5]([NH:8][C:9]2[CH:13]=[C:12]([CH:14]3[CH2:16][CH2:15]3)[NH:11][N:10]=2)=[N:6][CH:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 118390048HCID 118390048, compound

Product 1

HCID 118390062HCID 118390062, compoundYield 199.4%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of tert-butyl 9-((5-chloro-2-((5-cyclopropyl-1H-pyrazol-3-yl)amino)pyrimidin-4-yl)amino)-3-azaspiro[5.5]undecane-3-carboxylate (364 mg, 0.7251 mmol) in DCM (10 mL) was added a solution of HCl in ethyl acetate (20 mL, 60 mmol). The reaction was stirred overnight at rt and then concentrated in vacuo to give the title compound as a yellow solid (317 mg, 99%).

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-efc04ad1b63d4615bf0ee8197c06f7c3
Source dataset
uspto-grants-2016_08
Patent number
US09403801B2

Reaction notes

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