Hydrochloric Acid → HCID 178483276, compound

HRID 1480436Notes

Reaction equation

HRID 1480436 reaction equation
[CH3:1][N:2]([CH2:10][CH2:11][CH:12]1[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]1)[C:3]([C:5]1[N:6]=[N:7][NH:8][CH:9]=1)=[O:4].Cl.O1CCOCC1>CCOC(C)=O>[CH3:1][N:2]([CH2:10][CH2:11][CH:12]1[CH2:13][CH2:14][NH:15][CH2:16][CH2:17]1)[C:3]([C:5]1[N:6]=[N:7][NH:8][CH:9]=1)=[O:4]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 178483293HCID 178483293, compound

Product 1

HCID 178483276HCID 178483276, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To tert-butyl 4-(2-(N-methyl-1H-1,2,3-triazole-4-carboxamido)ethyl)piperidine-1-carboxylate (step 2) (190 mg, 0.563 mmol) in EtOAc (5 ml) was added 4N HCl in dioxane (5 ml, 20.00 mmol). The mixture was stirred for 30 mins and concentrated under reduced pressure to give crude N-methyl-N-(2-(piperidin-4-yl)ethyl)-1H-1,2,3-triazole-4-carboxamide as a gum. This was used in the next step without further purification.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-8058b4b6dee845188f043dfeccfb93b0
Source dataset
uspto-grants-2016_08
Patent number
US09409895B2

Reaction notes

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