Potassium Carbonate → HCID 89995991, compound

HRID 1480795Notes

Reaction equation

HRID 1480795 reaction equation
[Cl:1][C:2]1[N:3]=[CH:4][C:5]2[C:10]([CH:11]=1)=[C:9]([C:12]1[CH:13]=[N:14][NH:15][CH:16]=1)[CH:8]=[CH:7][CH:6]=2.Cl.Cl[CH2:19][CH2:20][N:21]([CH3:23])[CH3:22].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[Cl:1][C:2]1[N:3]=[CH:4][C:5]2[C:10]([CH:11]=1)=[C:9]([C:12]1[CH:16]=[N:15][N:14]([CH2:19][CH2:20][N:21]([CH3:23])[CH3:22])[CH:13]=1)[CH:8]=[CH:7][CH:6]=2

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 11636816N,N-Dimethylaminoethyl chloride hydrochlorideHCID 89996121HCID 89996121, compound

Product 1

HCID 89995991HCID 89995991, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
190 °C

Procedure

A mixture of 3-chloro-5-(1H-pyrazol-4-yl)isoquinoline (Preparation 3, 28 mg, 0.122 mmol), 2-chloro-N,N-dimethylethanamine hydrochloride (35.1 mg, 0.244 mmol) and K2CO3 (50.5 mg, 0.366 mmol) in DMF (4 mL) was stirred at 190° C. under microwave irradiation for 90 minutes.

Sources & evidence

ORD record
ord-bcb78dab064144bc9abf78c700f66831
Source dataset
uspto-grants-2016_08
Patent number
US09409907B2

Reaction notes

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