2-Bromopropane → HCID 90266390, compound

HRID 1483167Notes

Reaction equation

HRID 1483167 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[O:12][C:11](=[O:13])[NH:10][CH2:9]2)=[N:6][CH:7]=1.[H-].[Na+].[CH:16](Br)([CH3:18])[CH3:17].BrC1C=CC(C2OC(=O)N(C)C2)=NC=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[O:12][C:11](=[O:13])[N:10]([CH:16]([CH3:18])[CH3:17])[CH2:9]2)=[N:6][CH:7]=1

Participants

5

Reactant 4

HCID 63582-BromopropaneHCID 24758Sodium hydrideHCID 78128152HCID 78128152, compoundHCID 78128153HCID 78128153, compound

Product 1

HCID 90266390HCID 90266390, compoundYield 46.1%

Procedure

Compound 14b (125 mg, 0.51 mmol), NaH (51 mg, 1.28 mmol) and isopropyl bromide (125 mg, 1.02 mmol) reacted following the synthetic method of compound 14c to afford 67 mg colorless liquid, yield 46%.

Sources & evidence

ORD record
ord-a88fc92c8d5341aeaa724b0e8bf020c1
Source dataset
uspto-grants-2016_08
Patent number
US09416144B2

Reaction notes

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