4-Hydroxybenzaldehyde → HCID 178502732, compound

HRID 1485094Notes

Reaction equation

HRID 1485094 reaction equation
C1(CCO)CC1.OC1C=CC(C=O)=CC=1.[OH:16][C@@H:17]1[CH2:22][CH2:21][C@H:20]([C:23]([N:25]([O:27][CH3:28])[CH3:26])=[O:24])[CH2:19][CH2:18]1.[Cl:29][C:30]1[CH:35]=[CH:34][C:33](O)=[CH:32][CH:31]=1>>[Cl:29][C:30]1[CH:35]=[CH:34][C:33]([O:16][C@H:17]2[CH2:22][CH2:21][C@H:20]([C:23]([N:25]([O:27][CH3:28])[CH3:26])=[O:24])[CH2:19][CH2:18]2)=[CH:32][CH:31]=1

Participants

5

Reactant 4

HCID 1264-HydroxybenzaldehydeHCID 46844-ChlorophenolHCID 1376422-Cyclopropylethan-1-olHCID 178502733HCID 178502733, compound

Product 1

HCID 178502732HCID 178502732, compoundYield 33.9%

Procedure

Instead of 2-cyclopropylethanol and 4-hydroxybenzaldehyde, the compound (850 mg) obtained in step (1) above and p-chlorophenol (700 mg) were respectively used and treated by the same technique as in Reference Example 11-1 to give trans-4-(4-chlorophenoxy)-N-methoxy-N-methylcyclohexanecarboxamide as a colorless solid (458 mg).

Workup

  1. additiontreated by the same technique as in Reference Example 11-1

Sources & evidence

ORD record
ord-5f8512c94ce1462984e7d6e8349f2b9d
Source dataset
uspto-grants-2016_08
Patent number
US09422240B2

Reaction notes

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