HCID 85923149, compound → HCID 11298265, compound

HRID 1485122Notes

Reaction equation

HRID 1485122 reaction equation
C(OC([NH:11][CH2:12][C:13]([O:15][CH2:16][CH2:17][Si:18]([CH3:21])([CH3:20])[CH3:19])=[O:14])=O)C1C=CC=CC=1.[H][H]>C(OCC)(=O)C.[OH-].[OH-].[Pd+2]>[NH2:11][CH2:12][C:13]([O:15][CH2:16][CH2:17][Si:18]([CH3:21])([CH3:20])[CH3:19])=[O:14]

Participants

5

Reactant 2

HCID 85923149HCID 85923149, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 11298265HCID 11298265, compoundYield 89.1%

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 8857Ethyl AcetateSolvent

Procedure

To a solution in ethyl acetate (20.0 mL) of the compound (634 mg) obtained in step (1) above, 20% palladium hydroxide/carbon (63.0 mg) was added. The mixture was stirred at room temperature for an hour in a hydrogen atmosphere. After passing the reaction mixture through Celite (registered trademark), the filtrate was concentrated under reduced pressure to give the titled compound as a pale yellow oil (320 mg).

Workup

  1. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-4de129214d8849029ad4025fd67ef0c4
Source dataset
uspto-grants-2016_08
Patent number
US09422240B2

Reaction notes

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