Diethyl Ether → HCID 87270435, compound

HRID 1486663Notes

Reaction equation

HRID 1486663 reaction equation
[Cl:1][CH2:2][C:3]([O:5][CH2:6][CH3:7])=[O:4].[CH:8](OCC)=[O:9].[O-]CC.[Na+:16].C(OCC)C>CC(OC)(C)C>[Cl:1][CH:2]([C:3]([O:5][CH2:6][CH3:7])=[O:4])[CH2:8][O-:9].[Na+:16]

Participants

6

Reactant 4

HCID 3283Diethyl EtherHCID 7751Ethyl chloroacetateHCID 8025Ethyl formateHCID 2723922Sodium ethoxide

Product 1

HCID 87270435HCID 87270435, compound

Reagents, catalysts & solvents 1

HCID 15413tert-Butyl methyl etherSolvent

Procedure

89.31 g (728 mmol) of ethyl chloroacetate and 63.7 g (859.9 mmol) of ethyl formate were dissolved in 500 ml of MTBE. 259.77 g (801 mmol) of an ethanolic solution of sodium ethoxide were added dropwise while stirring. After 16 hours, the supernatant was decanted off from the precipitate formed, the residue was stirred with approx. 500 ml of diethyl ether and filtered with suction, and the solid was washed with a further 500 ml of diethyl ether and dried.

Workup

  1. customthe supernatant was decanted off from the precipitate
  2. customformed
  3. filtrationfiltered with suction
  4. washthe solid was washed with a further 500 ml of diethyl ether
  5. customdried

Sources & evidence

ORD record
ord-060ec61ead09485ab42386cade928536
Source dataset
uspto-grants-2016_08
Patent number
US09428487B2

Reaction notes

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