反应详情

To a stirred solution of 3-(3-aminophenyl)propanoic acid (1 g, 6.05 mmol) in 10 ml DMF, N-ethyl-N-isopropylpropan-2-amine (1.174 g, 9.08 mmol), cyclopropanamine (0.415 g, 7.26 mmol) were added, resulting clear solution was stirred at room temperature, HATU (3.45 g, 9.08 mmol) was added and the resulting mixture was stirred for 24 h at room temperature. Reaction Mixture was diluted with cold water and extraction with Ethyl Acetate (3×30 ml). The Combined organic layer was dried over sodium sulphate and evaporated under reduced pressure to give the crude compound, the crude compound was purified by column chromatography to afford the pure title compound (500 mg).

1. customresulting clear solution
2. stirringthe resulting mixture was stirred for 24 h at room temperature
3. customReaction Mixture
4. dry with materialThe Combined organic layer was dried over sodium sulphate
5. customevaporated under reduced pressure
6. customto give the crude compound
7. customthe crude compound was purified by column chromatography