反应详情

温度

35 °C

To a toluene (40 ml) solution of (4S,5R)-tert-butyl 4-(fluoromethyl)-5-(4-iodophenyl)-2,2-dimethyloxazolidine-3-carboxylate (2.0 g, 4.6 mmols) is added ethynyltrimethylsilane (451 mg, 4.6 mmols), copper (I)iodide (88 mg, 0.46 mmols, 0.1 equivs), Bis(triphenylphosphine)palladium(II) dichloride (165 mg, 0.23 mmols, 0.05 equivs) and piperidine (782 mg, 9.2 mmols, 2 equivs). The mixture is heated in an atmosphere of nitrogen at 35° C. for six hours. The mixture is filtered through a pad of Celite. The pad of Celite is washed with ethylacetate (2×15 ml). The combined organic filtrates were concentrated using rotary evaporation at reduced pressure to give a crude viscous oil. The oil is purified by flash column chromatography (grading from 100% hexanes to 15% EtOAc) to give the title compound (1.65 g): m/z (CI) 306 ([M+H]+−Boc).

1. filtrationThe mixture is filtered through a pad of Celite
2. washThe pad of Celite is washed with ethylacetate (2×15 ml)
3. concentrationThe combined organic filtrates were concentrated
4. customevaporation at reduced pressure
5. customto give a crude viscous oil
6. customThe oil is purified by flash column chromatography (grading from 100% hexanes to 15% EtOAc)