Ethane, 2-bromo-1,1-diethoxy- → HCID 178501172, compound

HRID 1490121Notes

Reaction equation

HRID 1490121 reaction equation
C(OC(OCC)CNC1C=CC([CH:13]2[CH2:18][CH2:17][N:16]([C:19](=[O:24])C(F)(F)F)[CH2:15][CH2:14]2)=CC=1)C.[F:28][C:29]([F:46])([F:45])[C:30]([N:32]1[CH2:37][CH2:36][CH:35]([C:38]2[CH:44]=[CH:43][C:41]([NH2:42])=[CH:40][CH:39]=2)[CH2:34][CH2:33]1)=[O:31].C([O:49][CH:50]([O:53][CH2:54]C)[CH2:51]Br)C.[CH2:56](N(C(C)C)C(C)C)[CH3:57]>C1CCCCC1.C(OCC)(=O)C>[CH3:54][O:53][C:50]([C@H:51]1[CH2:13][CH2:18][C@H:17]([N:16]2[CH:15]=[CH:14][N:42]([C:41]3[CH:43]=[CH:44][C:38]([CH:35]4[CH2:36][CH2:37][N:32]([C:30](=[O:31])[C:29]([F:28])([F:45])[F:46])[CH2:33][CH2:34]4)=[CH:39][CH:40]=3)[C:19]2=[O:24])[CH2:57][CH2:56]1)=[O:49]

Participants

6

Reactant 4

HCID 74852Ethane, 2-bromo-1,1-diethoxy-HCID 81531DiisopropylethylamineHCID 53999350HCID 53999350, compoundHCID 54263894HCID 54263894, compound

Product 1

HCID 178501172HCID 178501172, compound

Reagents, catalysts & solvents 1

HCID 21867204Cyclohexane ethylacetateSolvent

Procedure

The N-(2,2-diethoxyethyl)-4-(1-trifluoroacetyl-4-piperidinyl)-aniline use as amine [Rf value: 0.90 (silica gel; cyclohexane/ethyl acetate=1:3] is obtained by reacting 4-(1-trifluoroacetyl-4-piperidinyl)-aniline with bromoacetaldehyde-diethylacetal in the presence of N-ethyl-diisopropylamine.

Sources & evidence

ORD record
ord-12840f38ea624693874165599391aa6d
Source dataset
uspto-grants-1997_10
Patent number
US05681841

Reaction notes

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