HRID1490380

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8021

Diethylamine

C4H11N

结构：O=C(O)CCCC=C(c1ccc(CCNS(=O)(=O)c2ccc(Cl)cc2)cc1)c1cccnc1

HCID65971

6-[4-[2-[[(4-Chlorophenyl)sulfonyl]amino]ethyl]phenyl]-6-(3-pyridinyl)-5-hexenoic acid

C25H25ClN2O4S

HCID68263

1,1'-Carbonylbis(1H-imidazole)

C7H6N4O

PRODUCTS

生成物

结构：CCN(CC)C(=O)CCCC=C(c1ccc(CCNS(=O)(=O)c2ccc(Cl)cc2)cc1)c1cccnc1

HCID54283860

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

1.0 g of 6-(4-(2-(4-chlorobenzenesulphonylamino)ethyl)phenyl)-6-(3-pyridyl)hex-5-enoic acid are dissolved in 15 ml of tetrahydrofuran and stirred for 15 minutes with 0.49 g of carbonyldiimidazole. Then 1 ml of diethylamine is added and the mixture is refluxed for 2 hours. It is then concentrated by evaporation and the residue is taken up in ethyl acetate and dried. Finally, it is chromatographed over a silica gel column using ethyl acetate as eluant.

WORKUP

后处理

temperaturethe mixture is refluxed for 2 hours
concentrationIt is then concentrated by evaporation
customdried
customFinally, it is chromatographed over a silica gel column

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9d06988d68ac4cf0a3a71af0f8392785
来源数据集: uspto-grants-1997_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05681961
来源说明: uspto-grants-1997_10

反应 SMILES

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][CH2:12][CH2:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]([C:28]3[CH:29]=[N:30][CH:31]=[CH:32][CH:33]=3)=[CH:21][CH2:22][CH2:23][CH2:24][C:25](O)=[O:26])=[CH:16][CH:15]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.C(N1C=CN=C1)(N1C=CN=C1)=O.[CH2:46]([NH:48][CH2:49][CH3:50])[CH3:47]>O1CCCC1>[CH2:46]([N:48]([CH2:49][CH3:50])[C:25](=[O:26])[CH2:24][CH2:23][CH2:22][CH:21]=[C:20]([C:17]1[CH:16]=[CH:15][C:14]([CH2:13][CH2:12][NH:11][S:8]([C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=2)(=[O:10])=[O:9])=[CH:19][CH:18]=1)[C:28]1[CH:29]=[N:30][CH:31]=[CH:32][CH:33]=1)[CH3:47]