HCID 2774264, compound → HCID 70975102, compound
Reaction equation
CN(C)c1ccccc1F>B1Oc2ccccc2O1.CC(C)(O)C(C)(C)O.CCN(CC)CC.Cc1ccccc1.Fc1c(F)c(F)c(B(c2c(F)c(F)c(F)c(F)c2F)c2c(F)c(F)c(F)c(F)c2F)c(F)c1F>CN(C)c1ccc(B2OC(C)(C)C(C)(C)O2)cc1FParticipants
7
Conditions
- Temperature
- 120 °C
Procedure
Prepared from 2-fluoro-N,N-dimethylaniline (1g, 27.8 mg, 0.200 mmol, 1.00 equiv) and catBH (36.0 mg, 0.300 mmol, 1.50 equiv) according to GP 1. The title compound was purified by flash column chromatography using cyclohexane/EtOAc/Et3N (30/1/1) as eluent to afford 3g (22.2 mg, 42%) as a white solid.
Sources & evidence
- ORD record
- ord-c97bc2351f1641abbf2646050cc1f606
- Source dataset
- Borylation dataset from Roche
Reaction notes
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