alpha,alpha,alpha,3-Tetrafluorotoluene → 2-[2-Fluoro-4-(trifluoromethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

HRID 1490672Notes

Reaction equation

HRID 1490672 reaction equation
Fc1cccc(C(F)(F)F)c1>C1=CCCC=CCC1.C1=CCCC=CCC1.C1CCOC1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COc1ccccn1.C[OH2+].C[OH2+].[Ir].[Ir]>CC1(C)OB(c2ccc(C(F)(F)F)cc2F)OC1(C)C

Participants

6

Reactant 1

HCID 67867alpha,alpha,alpha,3-Tetrafluorotoluene

Product 1

HCID 177502482-[2-Fluoro-4-(trifluoromethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolaneYield 37%

Reagents, catalysts & solvents 4

HCID 742012-MethoxypyridineReagentHCID 2733548Bis(pinacolato)diboraneReagentHCID 76001521Bis(1,5-cyclooctadiene)dimethoxydiiridiumCatalystHCID 8028TetrahydrofuranSolvent

Conditions

Temperature
80 °C

Sources & evidence

ORD record
ord-f60e671c359d4e59b64c47d7dac588af
Source dataset
Borylation dataset from Roche

Reaction notes

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