4-Cyanophenol → 4-Methoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile

HRID 1490702Notes

Reaction equation

HRID 1490702 reaction equation
N#Cc1ccc(O)cc1>C1=CCCC=CCC1.C1=CCCC=CCC1.C1CCCCC1.CC(C)(C)c1ccnc(-c2cc(C(C)(C)C)ccn2)c1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CC1(C)OBOC1(C)C.C[OH2+].C[OH2+].[Ir].[Ir]>COc1ccc(C#N)c(B2OC(C)(C)C(C)(C)O2)c1.COc1ccc(C#N)cc1B1OC(C)(C)C(C)(C)O1

Participants

8

Reactant 1

HCID 130194-Cyanophenol

Product 2

HCID 467397344-Methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrileYield 21%HCID 597640214-Methoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrileYield 44%

Reagents, catalysts & solvents 5

HCID 2733548Bis(pinacolato)diboraneReagentHCID 27347684,4,5,5-Tetramethyl[1,3,2]dioxaborolaneReagentHCID 42491874,4'-Di-tert-butyl-2,2'-bipyridylReagentHCID 76001521Bis(1,5-cyclooctadiene)dimethoxydiiridiumCatalystHCID 8078CyclohexaneSolvent

Conditions

Temperature
80 °C

Sources & evidence

ORD record
ord-95200908db9e43dda4e01a8ca181a292
Source dataset
Borylation dataset from Roche

Reaction notes

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