反应详情

温度

25 °C

A mixture of methyl 3-fluoro-2-methylsulphonylbenzoate (10.9 g), potassium carbonate (7.8 g) and thiophenol (5.4 g) in N,N-dimethylformamide was stirred at 25° C. for six hours. Water and ethyl acetate were added and the resulting solid collected by filtration and combined with the solid obtained from washing the organic phase of the flitrate with brine, drying over magnesium sulphate, filtering and evaporating. This product was recrystallised from ethyl acetate to give 7.0 g of methyl 2-methylsulphonyl-3-phenylsulphenylbenzoate as white crystals, mp 151.1° C.

1. filtrationthe resulting solid collected by filtration
2. customobtained
3. washfrom washing the organic phase of the flitrate with brine
4. dry with materialdrying over magnesium sulphate
5. filtrationfiltering
6. customevaporating
7. customThis product was recrystallised from ethyl acetate