Chloroform → Diisopropylethylamine

HRID 1491809Notes

Reaction equation

C([N:3]([CH2:6][CH3:7])[CH2:4][CH3:5])C.ClCCl.[CH:11](Cl)(Cl)Cl.[CH2:15]1[CH2:19]OC[CH2:16]1>>[CH:6]([N:3]([CH:15]([CH3:19])[CH3:16])[CH2:4][CH3:5])([CH3:7])[CH3:11]

Participants

Reactant 4

HCID 6212Chloroform

HCID 6344Dichloromethane

HCID 8028Tetrahydrofuran

HCID 8471Triethylamine

Product 1

HCID 81531Diisopropylethylamine

Procedure

in the presence of an organic base such as triethylamine or diisopropylethylamine, and an inert organic solvent such as dichloromethane, chloroform or THF, under an inert atmosphere such as argon at a reduced temperature of from about -20° to about 15° C., to form the sulfonamide I of the invention.

Sources & evidence

ORD record: ord-61606d4c10454816a563d90ef714f9e7
Source dataset: uspto-grants-1994_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05371091

Reaction notes

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