Bromoacetyl bromide → HCID 15926211, compound

HRID 1493860Notes

Reaction equation

HRID 1493860 reaction equation
[CH3:1][NH:2][C:3]1[CH:8]=[CH:7][C:6]([Cl:9])=[CH:5][C:4]=1[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.[Br:17][CH2:18][C:19](Br)=[O:20]>C(OCC)(=O)C>[CH3:1][N:2]([C:19](=[O:20])[CH2:18][Br:17])[C:3]1[CH:8]=[CH:7][C:6]([Cl:9])=[CH:5][C:4]=1[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

4

Reactant 2

HCID 61147Bromoacetyl bromideHCID 15926210HCID 15926210, compound

Product 1

HCID 15926211HCID 15926211, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The N-methyl 2-benzyl-4-chloroaniline (10.8 g) in solution in ethyl acetate is treated at 5° C. with 4.9 ml of bromoacetyl bromide. After 1 hour at room temperature, decantation and washing with water, the solution is concentrated. Upon crystallization, N-methyl 2'-benzyl-4'-chloro-bromoacetanilide is obtained (12.21 g). MP=78° C.

Workup

  1. washdecantation and washing with water
  2. concentrationthe solution is concentrated
  3. customUpon crystallization

Sources & evidence

ORD record
ord-d88c985b3e9648269ede4175f0f2c584
Source dataset
uspto-grants-1991_06
Patent number
US05025015

Reaction notes

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