反应详情

To a solution of 63.34g (0.23 mole) of diethyl [3-(3-pyridyl)-propyl]malonate in 1.1L dimethylformamide is in small portions 9.91 g (0.25 mole) of sodium hydride as a 60% dispension in oil. After stirring at room temperature for 0.5 hours, 28 mL (0.23 mole) of 1-bromo-4-chlorobutane is added and then heated to 60° for 10 hours. Then 68.26 g (0.46 mole) sodium iodide is added followed by 44.44 g (0.68 mole) sodium azide and 9.0 g crown ether 18-Crown-6. The reaction mixture is heated for 15 hours at 60°, is then cooled and poured on ice. The mixture is then extracted with ether (4×500 mL). Combined organic extracts are extracted with 1N aqueous hydrochloric acid (1×200, 2×100 mL). Combined aqueous extract is adjusted to pH 8 by addition of solid sodium bicarbonate and then extracted with ether (3×300 mL). Combined organic extracts are washed with water (3×100 mL), brine (1×300 mL), dried (MgSO4), filtered and then evaporated to dryness to give diethyl [4-azidobutyl][3-(3-pyridyl)-propyl]-malonate as an oil.

1. temperatureheated to 60° for 10 hours
2. temperatureThe reaction mixture is heated for 15 hours at 60°
3. temperatureis then cooled
4. additionpoured on ice
5. extractionThe mixture is then extracted with ether (4×500 mL)
6. extractionCombined organic extracts are extracted with 1N aqueous hydrochloric acid (1×200, 2×100 mL)
7. extractionCombined aqueous extract
8. additionis adjusted to pH 8 by addition of solid sodium bicarbonate
9. extractionextracted with ether (3×300 mL)
10. washCombined organic extracts are washed with water (3×100 mL), brine (1×300 mL)
11. dry with materialdried (MgSO4)
12. filtrationfiltered
13. customevaporated to dryness