Water → HCID 10087643, compound

HRID 1494124Notes

Reaction equation

HRID 1494124 reaction equation
[N:1]([CH2:4][CH2:5][CH2:6][CH2:7][CH:8]([CH2:16][CH2:17][CH2:18][C:19]1[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=1)[S:9][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=[N+]=[N-].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.O>O1CCCC1>[NH2:1][CH2:4][CH2:5][CH2:6][CH2:7][CH:8]([CH2:16][CH2:17][CH2:18][C:19]1[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=1)[S:9][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12]

Participants

5

Reactant 3

HCID 962WaterHCID 11776TriphenylphosphineHCID 10066486HCID 10066486, compound

Product 1

HCID 10087643HCID 10087643, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 0.1 g (0.28 mmol) ethyl 8-azido-4-[3-(3-pyridyl)propyl]-3-thia-octanoate in 0.7 mL tetrahydrofuran is added 0.082 g triphenylphosphine followed by 0.01 mL water. The mixture is stirred at room temperature for 52 hours and then evaporated to give ethyl 8-amino-4-[3-(3-pyridyl)-propyl]-3-thia-octanoate, NMR (CDCl3) delta 4.2 (q,2H), 3.2 (s,2H).

Workup

  1. customevaporated

Sources & evidence

ORD record
ord-2ed8bfe6dab04f14a928c5618b3b6aa6
Source dataset
uspto-grants-1991_06
Patent number
US05025025

Reaction notes

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