Iodoethane → HCID 13536438, compound

HRID 1494380Notes

Reaction equation

HRID 1494380 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[C:13]([C:14]([O:16][CH2:17][CH3:18])=[O:15])=[C:12]([CH3:19])[NH:11][C:10]2[CH2:20][O:21][C:22](=[O:23])[C:9]1=2.[CH:24]([N-]C(C)C)(C)[CH3:25].[Li+].C(I)C>O1CCCC1>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[C:13]([C:14]([O:16][CH2:17][CH3:18])=[O:15])=[C:12]([CH3:19])[N:11]([CH2:24][CH3:25])[C:10]2[CH2:20][O:21][C:22](=[O:23])[C:9]1=2

Participants

5

Reactant 3

HCID 6340IodoethaneHCID 2724682Lithium diisopropylamideHCID 13469493HCID 13469493, compound

Product 1

HCID 13536438HCID 13536438, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

50 mmol of ethyl 4-(2-chlorophenyl)-2-methyl-5-oxo-1,4,5,7-tetrahydrofuro-[3,4-b]pyridine-3-carboxylate are dissolved in tetrahydrofuran, and 50 mmol of lithium diisopropylamide followed by 50 mmol of ethyl iodide are added at -78° C. The mixture is heated to room temperature and stirred for 1 hour, and is worked up analogously to Example 1.

Workup

  1. additionare added at -78° C

Sources & evidence

ORD record
ord-d9778f7402f346689fe901083d8476fc
Source dataset
uspto-grants-1991_06
Patent number
US05026714

Reaction notes

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