Hydrochloric Acid → 1-Methyl-2-piperazinyl-8-chloro-1,2,3,4-tetrahydronaphthalene dihydrochloride

HRID 1494394Notes

Reaction equation

[CH3:1][CH:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[Cl:12])[CH2:5][CH2:4][C:3]1=O.[NH:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1.[BH4-].[Na+].[ClH:22]>>[ClH:12].[ClH:22].[CH3:1][CH:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[Cl:12])[CH2:5][CH2:4][CH:3]1[N:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1

Participants

Reactant 4

HCID 313Hydrochloric Acid

HCID 4837Piperazine

HCID 4311764Sodium borohydride

HCID 151372221-Methyl-8-chloro-2-tetralone

Product 1

HCID 678296621-Methyl-2-piperazinyl-8-chloro-1,2,3,4-tetrahydronaphthalene dihydrochloride

Procedure

Using the method of Example 11, 1.94 g (10 mmol) of 1-methyl-8-chloro-2-tetralone were treated with piperazine followed by reduction with sodium borohydride and treatment with HCl to produce 0.67 g of the title compound as colorless crystals; m.p. >200° C.

Sources & evidence

ORD record: ord-a98451ae542c42ca9dde70add5a22502
Source dataset: uspto-grants-1991_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05026707

Reaction notes

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