Dimethylformamide → N-(5-tert-butyl-2-methoxy-3-(methylsulfonamido)phenyl)-2-(4-(2-morpholinopyrimidin-4-yloxy)naphthalen-1-yl)-2-oxoacetamide

HRID 149647Notes

Reaction equation

HRID 149647 reaction equation
[CH:53]([N:54]([CH2:55][CH3:56])[CH:57]([CH3:58])[CH3:59])([CH3:60])[CH3:61].[Cl:29][C:30]([C:31]([Cl:32])=[O:33])=[O:34].[Cl:62][CH2:63][Cl:64].[NH2:35][c:36]1[c:37]([O:51][CH3:52])[c:38]([NH:46][S:47](=[O:48])(=[O:49])[CH3:50])[cH:39][c:40]([C:42]([CH3:43])([CH3:44])[CH3:45])[cH:41]1.[O:1]1[CH2:2][CH2:3][N:4]([c:7]2[n:8][cH:9][cH:10][c:11]([O:13][c:14]3[cH:15][cH:16][c:17]([C:24]([C:25](=[O:26])[OH:27])=[O:28])[c:18]4[cH:19][cH:20][cH:21][cH:22][c:23]34)[n:12]2)[CH2:5][CH2:6]1.[O:65]=[CH:66][N:67]([CH3:68])[CH3:69]>>[O:1]1[CH2:2][CH2:3][N:4]([c:7]2[n:8][cH:9][cH:10][c:11]([O:13][c:14]3[cH:15][cH:16][c:17]([C:24]([C:25](=[O:27])[NH:35][c:36]4[c:37]([O:51][CH3:52])[c:38]([NH:46][S:47](=[O:48])(=[O:49])[CH3:50])[cH:39][c:40]([C:42]([CH3:43])([CH3:44])[CH3:45])[cH:41]4)=[O:28])[c:18]4[cH:19][cH:20][cH:21][cH:22][c:23]34)[n:12]2)[CH2:5][CH2:6]1

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 6344DichloromethaneHCID 65578Oxalyl chlorideHCID 81531DiisopropylethylamineHCID 10214710N-(3-amino-5-tert-butyl-2-methoxy-phenyl)-methanesulfonamideHCID 59379818[4-(2-Morpholin-4-yl-pyrimidin-4-yl-oxy)-naphthalen-1-yl]-oxo-acetic acid

Product 1

HCID 16734161N-(5-tert-butyl-2-methoxy-3-(methylsulfonamido)phenyl)-2-(4-(2-morpholinopyrimidin-4-yloxy)naphthalen-1-yl)-2-oxoacetamide

Sources & evidence

ORD record
ord-e2ea5e896267481c9304a9df82a93f12
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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