Hydrochloric Acid → HCID 86712489, compound

HRID 1496831Notes

Reaction equation

HRID 1496831 reaction equation
Cl.C(OC([NH:9][CH:10]([C:53]([OH:55])=[O:54])[CH2:11][CH2:12][NH:13][S:14]([C:17]1[C:30]2[C:31]3=[C:32]4[C:27](=[CH:28][CH:29]=2)[C:26]([OH:33])=[CH:25][C:24]([OH:34])=[C:23]4[CH:22]=[CH:21][C:20]3=[C:19]([S:35](=[O:52])(=[O:51])[NH:36][CH2:37][CH2:38][CH:39]([C:48]([OH:50])=[O:49])[NH:40]C(OC(C)(C)C)=O)[CH:18]=1)(=[O:16])=[O:15])=O)(C)(C)C>C1COCC1>[NH2:40][CH:39]([C:48]([OH:50])=[O:49])[CH2:38][CH2:37][NH:36][S:35]([C:19]1[C:20]2[C:31]3=[C:32]4[C:23](=[CH:22][CH:21]=2)[C:24]([OH:34])=[CH:25][C:26]([OH:33])=[C:27]4[CH:28]=[CH:29][C:30]3=[C:17]([S:14](=[O:16])(=[O:15])[NH:13][CH2:12][CH2:11][CH:10]([C:53]([OH:55])=[O:54])[NH2:9])[CH:18]=1)(=[O:52])=[O:51]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86712490HCID 86712490, compound

Product 1

HCID 86712489HCID 86712489, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A 2 N aqueous solution of HCl was added in one portion to a solution of the bis-Boc derivative (8) synthesized above (1.658 g, 2.09 mmol) in THF (200 mL) and the mixture was stirred for 24 h at room temperature. The mixture was then evaporated to dryness under reduced pressure.

Workup

  1. customThe mixture was then evaporated to dryness under reduced pressure

Sources & evidence

ORD record
ord-fecf971c3abc46e592faff2dc51b52c0
Source dataset
uspto-grants-2015_12
Patent number
US09199928B2

Reaction notes

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