Potassium Carbonate → 1-(4-(3-Methoxy-4-nitrophenyl)piperazin-1-yl)ethanone

HRID 1496943Notes

Reaction equation

HRID 1496943 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4]([O:11][CH3:12])[CH:3]=1.[C:13]([N:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1)(=[O:15])[CH3:14].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH3:12][O:11][C:4]1[CH:3]=[C:2]([N:19]2[CH2:20][CH2:21][N:16]([C:13](=[O:15])[CH3:14])[CH2:17][CH2:18]2)[CH:7]=[CH:6][C:5]=1[N+:8]([O-:10])=[O:9]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 837951-AcetylpiperazineHCID 27792505-Fluoro-2-nitroanisole

Product 1

HCID 594418231-(4-(3-Methoxy-4-nitrophenyl)piperazin-1-yl)ethanone

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The compound obtained in Step 1 above (300 mg), N-acetylpiperazine (300 mg), and potassium carbonate (500 mg) were dissolved in dimethylformamide (3 mL) and reacted at 80° C. overnight. The dimethylformamide of the reaction mixture was removed under reduced pressure, and added with water to form a solid. The solid was filtered to obtain a target compound as a yellow solid.

Workup

  1. customreacted at 80° C. overnight
  2. customThe dimethylformamide of the reaction mixture was removed under reduced pressure
  3. additionadded with water
  4. customto form a solid
  5. filtrationThe solid was filtered

Sources & evidence

ORD record
ord-fa5b27d980f7426d846e0ee1448a2787
Source dataset
uspto-grants-2015_12
Patent number
US09199944B2

Reaction notes

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