Potassium Carbonate → HCID 118105716, compound

HRID 1496954Notes

Reaction equation

HRID 1496954 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:3]=1.[C:19]([N:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1)(=[O:21])[CH3:20].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH2:12]([O:11][C:4]1[CH:3]=[C:2]([N:25]2[CH2:26][CH2:27][N:22]([C:19](=[O:21])[CH3:20])[CH2:23][CH2:24]2)[CH:7]=[CH:6][C:5]=1[N+:8]([O-:10])=[O:9])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 837951-AcetylpiperazineHCID 110969082-(Benzyloxy)-4-fluoro-1-nitrobenzene

Product 1

HCID 118105716HCID 118105716, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The compound obtained in Step 1 above (300 mg), N-acetylpiperazine (300 mg), and potassium carbonate (500 mg) were dissolved in dimethylformamide (3 mL) and reacted at 80° C. overnight. The dimethylformamide of the reaction mixture was removed under reduced pressure, and added with water to form a solid. The solid was filtered to obtain a target compound as a yellow solid.

Workup

  1. customreacted at 80° C. overnight
  2. customThe dimethylformamide of the reaction mixture was removed under reduced pressure
  3. additionadded with water
  4. customto form a solid
  5. filtrationThe solid was filtered

Sources & evidence

ORD record
ord-2f9f3ef35785407ca688fb3ad245174a
Source dataset
uspto-grants-2015_12
Patent number
US09199944B2

Reaction notes

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