反应详情

To a solution of 4-(4-hydroxyphenyl)butanoic acid (2.00 g) in N,N-dimethylformamide (28.0 mL) were added potassium carbonate (1.61 g) and benzyl bromide (1.46 mL), followed by stirring at room temperature overnight. The reaction suspension was concentrated under reduced pressure, and then to the residue was added water, followed by extraction with ethyl acetate. The organic layer was washed with water and a saturated aqueous sodium chloride solution, then dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane-ethyl acetate) to obtain benzyl 4-(4-hydroxyphenyl)butanoate (2.64 g).

1. concentrationThe reaction suspension was concentrated under reduced pressure
2. additionto the residue was added water
3. extractionfollowed by extraction with ethyl acetate
4. washThe organic layer was washed with water
5. dry with materiala saturated aqueous sodium chloride solution, then dried over anhydrous sodium sulfate
6. concentrationconcentrated under reduced pressure
7. customThe residue was purified by silica gel column chromatography (hexane-ethyl acetate)