Phosphorus oxychloride → HCID 54588982, compound

HRID 1500243Notes

Reaction equation

HRID 1500243 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[N:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1)[C:5](O)=[O:6].O=P(Cl)(Cl)Cl.[N-:22]=[N+:23]=[N-:24].[Na+]>CN(C=O)C>[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[N:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1)[C:5]([N:22]=[N+:23]=[N-:24])=[O:6]

Participants

5

Reactant 3

HCID 24813Phosphorus oxychlorideHCID 33557Sodium AzideHCID 121095953-Fluoro-4-morpholinobenzoic acid

Product 1

HCID 54588982HCID 54588982, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

This compound may be prepared from (14) in a one pot reaction utilizing POCl3 in DMF (Vilsmeier complex) and NaN3 following the literature procedure of Sridhar et al. (Syn. Comm. 2003, 33, 607-611).

Sources & evidence

ORD record
ord-9ec38df0238b438fb578f2d1c4caba17
Source dataset
uspto-grants-2015_12
Patent number
US09206141B2

Reaction notes

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