Hydrochloric Acid → HCID 117778124, compound

HRID 1500501Notes

Reaction equation

HRID 1500501 reaction equation
C(OC([N:8]([CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([CH:23]2[CH2:27][CH2:26][CH2:25][CH2:24]2)[CH:18]=1)C(=O)OC(C)(C)C)=O)(C)(C)C.[ClH:28]>C(OCC)(=O)C>[ClH:28].[CH:23]1([C:19]2[CH:18]=[C:17]([CH2:16][NH2:8])[CH:22]=[CH:21][CH:20]=2)[CH2:24][CH2:25][CH2:26][CH2:27]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 117778084HCID 117778084, compound

Product 1

HCID 117778124HCID 117778124, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To tert-butyl N-tert-butoxycarbonyl-N-[(3-cyclopentylphenyl)methyl]carbamate (4.70 g), a solution of hydrogen chloride in ethyl acetate (4 M, 50 mL) was added, and the mixture was then stirred at room temperature for 2 hours. The reaction solution was concentrated under reduced pressure, and ether (200 mL) was added to the residue. The resulting suspension was filtered, and the product collected by filtration was dried under reduced pressure to obtain the title compound (2.64 g).

Workup

  1. concentrationThe reaction solution was concentrated under reduced pressure, and ether (200 mL)
  2. additionwas added to the residue
  3. filtrationThe resulting suspension was filtered
  4. filtrationthe product collected by filtration
  5. customwas dried under reduced pressure

Sources & evidence

ORD record
ord-24f60f316f044bf19a0b0059200c3cd0
Source dataset
uspto-grants-2015_12
Patent number
US09206168B2

Reaction notes

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