Diisopropylethylamine → HCID 67370966, compound

HRID 1500760Notes

Reaction equation

HRID 1500760 reaction equation
C(N(C(C)C)CC)(C)C.C(O)(=O)C.[O:14]1[CH2:19][CH2:18][CH:17]([NH2:20])[CH2:16][CH2:15]1.Cl[C:22]1[C:27]([N+:28]([O-:30])=[O:29])=[CH:26][N:25]=[C:24]([C:31]2[CH:32]=[N:33][N:34]3[CH:39]=[CH:38][N:37]=[CH:36][C:35]=23)[N:23]=1>O1CCCC1>[N+:28]([C:27]1[C:22]([NH:20][CH:17]2[CH2:18][CH2:19][O:14][CH2:15][CH2:16]2)=[N:23][C:24]([C:31]2[CH:32]=[N:33][N:34]3[CH:39]=[CH:38][N:37]=[CH:36][C:35]=23)=[N:25][CH:26]=1)([O-:30])=[O:29]

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 44118770Acetic acid--oxan-4-amine (1/1)HCID 86680708HCID 86680708, compound

Product 1

HCID 67370966HCID 67370966, compoundYield 70.1%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Diisopropylethylamine (2.30 mL, 13.20 mmol) and tetrahydro-2H-pyran-4-amine acetate (526 mg, 3.28 mmol) were added to a stirred suspension of 3-(4-chloro-5-nitropyrimidin-2-yl)pyrazolo[1,5-a]pyrazine (Preparation 24e, 0.91 g, 3.29 mmol) in tetrahydrofuran (15 mL) and the mixture was stirred at room temperature for 3 hours. The solvent was evaporated and water was added. The mixture was filtered to give the title compound (0.785 g, 70%) as a yellow solid.

Workup

  1. customThe solvent was evaporated
  2. additionwater was added
  3. filtrationThe mixture was filtered

Sources & evidence

ORD record
ord-b8b9383b703f4b98b177f259d1bf91f1
Source dataset
uspto-grants-2015_12
Patent number
US09206183B2

Reaction notes

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