Triethylamine → HCID 89924133, compound

HRID 1500928Notes

Reaction equation

HRID 1500928 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5](F)=[C:4]([N+:9]([O-:11])=[O:10])[CH:3]=1.[NH2:12][CH:13]1[CH2:20][C:16]2([CH2:19][O:18][CH2:17]2)[N:15]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH2:14]1.CCN(CC)CC>O1CCCC1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:12][CH:13]2[CH2:20][C:16]3([CH2:17][O:18][CH2:19]3)[N:15]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH2:14]2)=[C:4]([N+:9]([O-:11])=[O:10])[CH:3]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 676604-Chloro-1-fluoro-2-nitrobenzeneHCID 899240621538626-90-2

Product 1

HCID 89924133HCID 89924133, compoundYield 76.1%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 4-chloro-1-fluoro-2-nitrobenzene (264 mg, 1.50 mmol), tert-butyl 7-amino-2-oxa-5-azaspiro[3.4]octane-5-carboxylate (343 mg, 1.50 mmol) and NEt3 (0.44 mL, 3.12 mmol) in 10 mL of tetrahydrofuran was stirred at room temperature overnight and then heated under reflux for 5 hours. The resulting mixture was concentrated in vacuo and the residue was purified by flash column (eluting with 0-5% MeOH in DCM) to afford tert-butyl 7-[(4-chloro-2-nitrophenyl)amino]-2-oxa-5-azaspiro[3.4]octane-5-carboxylate (438 mg, yield: 76.1%) as an orange solid.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 5 hours
  3. concentrationThe resulting mixture was concentrated in vacuo
  4. customthe residue was purified by flash column (eluting with 0-5% MeOH in DCM)

Sources & evidence

ORD record
ord-cc5f41817c5a4f36be19ea90255e1364
Source dataset
uspto-grants-2015_12
Patent number
US09206191B2

Reaction notes

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